Author: Ashu Chaudharya* and R.V. Singhb

DOI:

The coordination and organometallic chemistry of metal nitrogen and metal-sulfur bonded compounds have come to occupy a prominent position in the research due to their economical importance in the field of agricultural, medicinal and industrial chemistry. Although N4-tetraamide derivatives of transition metal ions have been synthesized and some of their structures, interaction with main group metal ions and the formation of their coordination complexes are subjects of current interest. This communication deals with a description of synthetic procedure and structural characterization on the bais of analytical and spectroscopic techniques of a new class of coordination compounds of organotin(II) with N4-tetraamide moiety derived by the dicarboxylic acids and 1,4-diaminobutane. Attempts have been made to assess the comparative growth-inhibiting potential of the synthesized complexes against a variety of fungal and bacterial strains. The results demonstrate that the concentrations reached levels sufficient to inhibit and kill the pathogens. The results of the biological studies have also been compred with a conventional standards, Bavistin and Streptomycin, taken for antifungal and antibacteral activities, respectively. The emphasis has been given in vivo on male rats by performing bio-chemistry and fertility test. The results of these findings have been discussed in detail.

Keywords: Organotin, Macrocyclic complexes, biochemical perspective, antifertility activity and pharmacological evaliation