Author: S. Jyothi, P. Reddy Prasad, C.Nageswara Reddy, G. Anil Kumar and A. Padmaja

DOI: http://doi.org/10.31788/RJC.2022.1558222

2-amino-4,6-diarylpyrimidine (1mmol) (1) and methyl 2-(benzoxazoylsulfonyl) acetate were irradiated in an ultrasonic bath at a low frequency of 35 kHz at room temperature to synthesize a variety of benzazolysulfonyl primidinyl acetamide derivatives. As a result of the antibacterial activity examined, the substances were highly potent towards Gram-positive bacteria (S. aureus and B. subtilis) compared to Gram-negative bacteria (S. aureus & B. subtilis and P. aeruginosa & K. pneumoniae), respectively. Compounds with electron-withdrawing groups 15c, 15e, 16c, and 16e showed superior antibacterial and antifungal activity against B. subtilis and A. niger compared to conventional medications, chloramphenicol, and ketoconazole, with MICs of 6.25 µg/ml that were comparable to those of the conventional medications.

Keywords: Ultrasonication, Ionic Liquid, Antifungal, Antimicrobial, Bacteria, Frequency.