Author: Donka Suresh Babu, Doddaga Srinivasulu, Valaparla Bala Yesu, V.V.P.C. Narayana, Murali Vatturu, Sajitha Kethineni and Meriga Balaji

DOI: http://doi.org/10.31788/RJC.2023.1618008

In pursuit of a biodynamically potent molecule, we have attempted to synthesize derivatives of piperazine by incorporating them into the Rosuvastatin intermediate. The reason behind this is that heterocyclic compounds with nitrogen atoms in their ring structure, such as pyrimidine, have great potential as drug design scaffolds. By doping piperazine into the Rosuvastatin intermediate, a series of new derivatives made up of aryl-amides, acetamides, and sulfonamides were produced. These derivatives were then assessed for their antimicrobial activity, with a few showing promising results

Keywords: Rosuvastatin Intermediate, Piperazine, Amide, Anti-microbial activity.