EXTRACTION, STRUCTURAL ELUCIDATION, AND FUNCTIONAL EVALUATION OF A NOVEL Boswellia Serrata GUM POLYSACCHARIDE AS A NATURAL SUPERDISINTEGRANT
A novel water-soluble polysaccharide (BSP) was isolated from the oleo gum-resin of Boswellia serrata usinghot- water extraction, ethanol precipitation, dialysis, and lyophilisation. FTIR analysis confirmed characteristiccarbohydrate functional groups, with signals at 826 and 868 cm-1 indicating both α- and β-glycosidic configurations. Monosaccharide profiling and NMR spectroscopy identified glucose and mannose as the major constituents. Linkage analysis by GC–MS revealed →4)-Glcp-(1→ and →3)-Manp-(1→ glycosidic linkages, establishing BSPasa glucomannan heteropolysaccharide. BSP was incorporated into fast-disintegrating herbal tablet formulations andcompared with sodium starch glycolate and crospovidone. Micromeritic evaluation showed that BSP significantlyimproved flowability, reflected by lower Carr’s index and Hausner ratio. All formulations met pharmacopoeial standards for hardness, friability, thickness, and weight variation. BSP-containing tablets (F8–F9) demonstratednotably superior disintegration performance, with F9 achieving the fastest disintegration time (3.00 ± 0.07 min), outperforming both synthetic superdisintegrants. The findings indicate that the structurally defined glucomannanfrom B. serrata exhibits excellent disintegration efficiency and desirable processing characteristics. BSP represents asafe, naturally sourced from life on land, and cost-effective alternative to conventional synthetic superdisintegrants, with promising application potential in fast-dissolving tablet formulations. Further optimization and in vivoevaluation are recommended to support product development and industrial translation.
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