Author: M. J. Pimpale and H. P. Narkhede

DOI: http://doi.org/10.31788/RJC.2026.1919519

Creating heterocyclic compounds that can be used for medicine is an important area of study in medicinal chemistry. This study shows how to create new 3-chloro-2-hydrazinylpyridine compounds in a special machine called a rotor- stator spinning disc reactor (RS-SDR). The special design of the RS-SDR allows for better mixing, efficient heat transfer, and accurate control of reaction conditions, making it easier and quicker to produce hydrazinylpyridinecompounds in larger amounts. By carefully designing molecules and adjusting the process conditions, we were ableto produce a lot of high-quality products in a safe and eco-friendly way. Our method is much faster and works better than traditional batch processes, even when solid materials are involved. Testing of certain compounds showedthat they have good abilities to fight germs and reduce inflammation. This suggests they could be important startingpoints for creating new medicines. These results show how combining continuous flow chemistry with designingring-shaped chemical structures can create useful molecules more sustainably and efficiently. This work shows howthe RS-SDR is a useful tool for speeding up the process of finding new drugs by allowing for environmentallyfriendly and larger-scale production.

Keywords: 3-Chloro-2-hydrazinylpyridine, Continuous Flow Chemistry, Rotor-Stator Spinning Disc Reactor, Heterocyclic Compounds, Bioactive Derivatives, Process Intensification, Antimicrobial and Anti-inflammatoryActivity.