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ANTIFUNGAL ACTIVITY FROM STEM AND LEAF CAPA EXTRACT (Blumea Balsamifera L.): TRADITIONAL MEDICINAL PLANT FROM SOUTH ACEH, INDONESIA


Author: Masyud, Khalisah, Saudah, Jailani, Irhamni, and S. Nurman
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Abstract

The use of synthetic chemicals for treating diabetic wounds has not yet demonstrated full effectiveness in promotingwound healing. Diabetic wounds generally heal slowly and are often referred to as gangrene. Fungal infections arecommonly found in these wounds, further delaying the healing process. Therefore, alternative therapeutic agentsderived from natural products are needed, as they are generally safer, have fewer side effects, and can acceleratewound healing in an environmentally friendly manner. The capa plant (Blumea balsamifera L.) has the potential toact as a treatment for diabetic wounds and to inhibit fungal growth. The urgency of this research lies in developingthe potential of local medicinal plants as new resources to replace synthetic chemicals that may cause adverse effects. This study also aims to explore additional benefits of medicinal plants traditionally used by communities for variousdiseases. This research was conducted through laboratory experiments, including the extraction of capa plant materials, phytochemical analysis of capa leaves, and antifungal assays comparing leaf and stemextracts usingdifferent solvents. The results showed that both leaf and stem extracts of capa were capable of inhibiting the growthof Candida albicans. The largest inhibition zone was observed in the stem extract using ethyl solvent (10 mm). Thestem extract exhibited stronger antifungal activity than the leaf extract, and both extracts demonstrated moderateinhibitory effects comparable to the positive control antifungal medicine. These findings indicate that capa leavesand stems contain antifungal compounds and have the potential to be developed as active ingredients for diabeticwounds.

Keywords: antifungal Activity, Blumea bassamifera, Traditional Medicinal Plant.






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