MICROWAVE-ASSISTED, ONE-POT SYNTHESIS OF NOVEL HEXA HYDRO IMIDAZO [1,2-a] PYRIDINE: WITH DIVERSE CATALYST SCREENING AND INSILICO-STUDIES
A microwave-assisted, one-pot, three-component synthesis of Imidazo [1,2-a] pyridine using four different catalystswas reported. The authors primarily focused on methodological development rather than synthesis of multiplederivatives, comparing reaction times and yields with those obtained under conventional conditions. Most importantly, in silico studies were conducted on the newly synthesised compound using the crystal structure of theenzyme 1A3 (PDB ID: 6TE5. Imidazo [1,2-a] pyridine derivatives are known inhibitors of aldehyde dehydrogenase1A3 (ALDH1A3), an enzyme whose overexpression is associated with various cancers, including breast, lung, brainand colon cancers.
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