SYNTHESIS, SPECTRAL CHARACTERISATION AND ANTIMICROBIAL STUDIES OF A NOVEL SYMMETRICAL AZINE
In this work, a novel symmetrical azine N,N′-bis(quinoxaline-2-carboxalidene)hydrazine (L) was synthesizedfromquinoxaline-2-carboxaldehyde and hydrazine hydrate by condensation reaction. The molecular structure of the azinewas thoroughly confirmed by elemental microanalysis along with FT IR, UV visible, and ¹HNMRspectral techniques, all of which supported the proposed structural framework. Antimicrobial activity studies were carriedout using the agar diffusion method, and the synthesized compound was evaluated against Escherichia coli as arepresentative Gram-negative bacterial strain. The experimental results revealed that the synthesized azine didnot exhibit notable antibacterial activity under the tested conditions. The absence of significant activity maybeattributed to several factors, including limited interaction with bacterial cell membranes, insufficient lipophilicitytopenetrate the bacterial envelope, or the lack of key functional groups typically associated with antimicrobial efficacy. These findings suggest that further structural modification or derivatization may be necessary to enhance thebiological potential of this class of compounds. It can be used as a ligand for the preparation of transition metal complexes, since metal coordination often enhances the biological activity of azine compounds.
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