Author: P.Thiruvasagam

DOI: http://doi.org/10.31788/RJC.2026.1929580

Aromatic nucleophilic substitution reactions are the main tool for synthesizing a variety of organic compounds andpolymers. Aromatic nucleophilic substitution reactions are enhanced by the electron-withdrawing groups. The first part of this review article discusses about the activation power of various electron-withdrawing groups. Theactivation power of electron-withdrawing groups is compared with the keto group of 4,4’-difluoro benzophenone, astandard activated dihalide undergoing facile nucleophilic displacement reactions. The second part of this reviewarticle discusses about the activation power of the amide group and its stability at high temperature. The amide- activated displacement reactions for the synthesis of monomers and polymers are discussed. The advantages of nucleophilic displacement reactions in polyamide synthesis, including yields and M.Wt of the polyamides, areanalyzed and reported.

Keywords: Nucleophilic Reaction, Electron Withdrawing Group, Activation Power, Amide Group, Bisfluoramide