Author: D. M. Tejashwini, K. R. Mahanthesha , K. R. Rajashekar and C. T. Keerthi Kumar

DOI: http://doi.org/10.31788/RJC.2026.1939822

Nickel manganese ferrite nanoparticle was synthesized via the conventional combustion method. XRDanalysisconfirms that the crystallite size of nickel manganese ferrite nanoparticle was found to be 24 nm. The bandgapwas2.27 eV as validated by UV-Visible spectroscopic analysis. The exterior morphology and elemental analysis of thesynthesized nanoparticles was confirmed by SEM and EDAX analysis. Employing cyclic voltammetryanddifferential pulse voltammetry, the electrochemical performance of nickel manganese ferrite nanoparticles for thedetermination of neurotransmitters and anticancer drugs in the presence of biomolecules was studied. Varyingthescan rate of the current-voltage cycle, anodic peak currents were recorded and studied, associated withneurotransmitters such as dopamine and anticancer drugs like erlotinib, in the presence of ascorbic acid. Byemploying a nickel manganese ferrite-based modified screen-printed electrode, it is feasible to knowthat thesynthesized nanoparticles are an effective material for the electrochemical sensing of ascorbic acid, dopamine anderlotinib simultaneously. These findings highlight the potential application of nickel manganese ferrite-basedmodified screen-printed electrode in biosensing and clinical diagnostics. By offering an affordable, highlysensitive and selective platform for multi-analyte detection, these discoveries considerably enhance nanostructuredferrite electrochemical sensors. The work improves analytical reliability by addressing important simultaneousdetection issues such as electrode stability and signal interference. Additionally, this study encourages further studies toward streamlined, real-time diagnostic systems by offering new directions for the fabrication of ferrite- based nanomaterials in biological sensing. The reported performance shows great promise for practical purposes inpoint-of-care testing, medication surveillance, and clinical diagnostics.

Keywords: Ascorbic Acid, Combustion Synthesis, Dopamine Sensing, Electrochemical Sensing, Erlotinib Sensing, Nickel Manganese Ferrite.